Over the recent years I happen to have made several small personal projects using Python's Flask web framework. The framework is designed to provide a very minimalistic "bottom-up" approach. It feels slightly less cluttered and imposing than some of the popular alternatives, thus fitting nicely for the projects a single person might typically want to hack up in a spare weekend. Minimalism of Flask does not mean it is somehow limited or unsuitable for larger projects - perhaps on the contrary, small size of the framework means there are fewer restrictions on what and how you can do with it.
What a small framework needs to be applied comfortably beyond its 6-line "Hello-World" use case, however, is a decent starter project template that would include some of the most common bells and whistles. And indeed, there happen to be several such templates available. I used parts of them over time in my own projects, however I always ended redoing/rewriting/renaming bits and pieces to fit my personal aesthetic needs. Eventually I got tired of renaming and packaged a Flask application template in the way I consistently prefer to use it. I am not sure whether it is objectively better or worse than the alternatives. None the less, if at some point you decide to give Flask a try, let me suggest you try this template of mine as your point of origin.